Postsurgical inflammatory response is not associated with increased serum cystatin C values
2010 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 43, no 13-14, 1138-1140 p.Article in journal (Refereed) Published
OBJECTIVES: Cystatin C is used both as a glomerular filtration (GFR) marker and a cardiovascular risk marker. There are several studies showing an association between cystatin C and inflammatory markers and it has been suggested that the inflammatory response in itself could result in elevated cystatin C levels. The aim of this study was to evaluate if an induced inflammatory response has an effect on cystatin C levels in humans. MATERIALS AND METHODS: CRP and cystatin C were analyzed in serum samples from orthopedic surgery patients (n=29). The patients were sampled prior to surgery and four and thirty days after surgery. RESULTS: The surgery induced a pronounced CRP elevation on day four, median 137.3 (interquartile range 104.1-178.2) mg/L compared to 1.94 (1.20-8.70) mg/L before surgery, P<0.001, but no significant difference in cystatin C levels before and four and thirty days after surgery could be seen. CONCLUSIONS: The orthopedic surgery-induced inflammatory response does not cause changes in cystatin C levels.
Place, publisher, year, edition, pages
2010. Vol. 43, no 13-14, 1138-1140 p.
Cystatin C, C-reactive protein, Glomerular filtration rate, Human, Inflammation, Surgery
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-132546DOI: 10.1016/j.clinbiochem.2010.07.004ISI: 000281721200021PubMedID: 20627098OAI: oai:DiVA.org:uu-132546DiVA: diva2:358270