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Postsurgical inflammatory response is not associated with increased serum cystatin C values
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (klinisk kemi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (biologisk struktur och funktion)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (biologisk struktur och funktion)
2010 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 43, no 13-14, 1138-1140 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Cystatin C is used both as a glomerular filtration (GFR) marker and a cardiovascular risk marker. There are several studies showing an association between cystatin C and inflammatory markers and it has been suggested that the inflammatory response in itself could result in elevated cystatin C levels. The aim of this study was to evaluate if an induced inflammatory response has an effect on cystatin C levels in humans. MATERIALS AND METHODS: CRP and cystatin C were analyzed in serum samples from orthopedic surgery patients (n=29). The patients were sampled prior to surgery and four and thirty days after surgery. RESULTS: The surgery induced a pronounced CRP elevation on day four, median 137.3 (interquartile range 104.1-178.2) mg/L compared to 1.94 (1.20-8.70) mg/L before surgery, P<0.001, but no significant difference in cystatin C levels before and four and thirty days after surgery could be seen. CONCLUSIONS: The orthopedic surgery-induced inflammatory response does not cause changes in cystatin C levels.

Place, publisher, year, edition, pages
2010. Vol. 43, no 13-14, 1138-1140 p.
Keyword [en]
Cystatin C, C-reactive protein, Glomerular filtration rate, Human, Inflammation, Surgery
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-132546DOI: 10.1016/j.clinbiochem.2010.07.004ISI: 000281721200021PubMedID: 20627098OAI: oai:DiVA.org:uu-132546DiVA: diva2:358270
Available from: 2010-10-21 Created: 2010-10-21 Last updated: 2017-12-12Bibliographically approved

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Larsson, Anders

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