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Pentraxin 3 Values During Normal Pregnancy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
2011 (English)In: Inflammation, ISSN 0360-3997, E-ISSN 1573-2576, Vol. 34, no 5, 448-451 p.Article in journal (Refereed) Published
Abstract [en]

Pentraxin 3 (PTX3) is an inflammatory molecule that has been reported to be a promising early biomarker for subsequent preeclampsia. The levels of PTX3 vary during pregnancy and it is thus a need to establish reference intervals during normal pregnancy. Repeated blood samples were collected from 52 healthy pregnant females. The samples were divided according to collection time into the following groups: week 7-17, week 17-24, week 24-28, week 28-31, week 31-34, week 34-38, before delivery and after delivery. The samples were analyzed for PTX3 with a sandwich ELISA and the 2.5 and 97.5 percentiles for each sample period was calculated. There was a continuous increase of serum PTX3 as pregnancy progressed. The increase was most evident after week 31 with the highest levels just before delivery.

Place, publisher, year, edition, pages
2011. Vol. 34, no 5, 448-451 p.
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-132552DOI: 10.1007/s10753-010-9252-xISI: 000294820200018PubMedID: 20852923OAI: oai:DiVA.org:uu-132552DiVA: diva2:358280
Available from: 2010-10-21 Created: 2010-10-21 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Oxidative Stress, Angiogenesis and Inflammation in Normal Pregnancy and Postpartum
Open this publication in new window or tab >>Oxidative Stress, Angiogenesis and Inflammation in Normal Pregnancy and Postpartum
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aims were to investigate oxidative stress (I), angiogenesis (II) and inflammation (III-IV) in healthy women during pregnancy and postpartum. Oxidative stress was estimated by measurement of 8-iso-PGF and the antioxidants α- and γ-tocopherol. The angiogenic factors PlGF, VEGF-A and the antiangiogenic factor sFlt1 were measured to estimate angiogenesis. PTX3, IL-6, TNF-α and a PGF metabolite were measured to estimate inflammation.

Out of 52 included women, 15 had minor pregnancy complications and 37 were classified as normal. In study III data from all 52 women were used. For the other studies (I, II and IV) only data from the 37 women with normal pregnancy were used. Pregnancy was associated with increased levels of 8-iso-PGF with advancing gestational age. The median postpartum value corresponded to values observed in early gestation and a significant decrease was observed from late pregnancy to postpartum. Lipid-adjusted α- and γ-tocopherol levels decreased with advancing gestational age (I). PlGF increased from early pregnancy until weeks 29–30 and thereafter decreased until week 40. sFlt1 levels were relatively constant until weeks 29–30, when they increased, reaching a peak at weeks 39–40. Postpartum levels were low. The sFlt1:PlGF ratio decreased from weeks 9–12, was constantly low from weeks 19–20 to 37–38 and then increased to weeks 39–40. VEGF-A was detectable in only 8 % of the samples during pregnancy and in 64 % postpartum (II). There was a continuous increase of PTX3 as pregnancy progressed. The increase was most evident after week 31 with the highest levels just before delivery (III). IL-6 increased throughout pregnancy and remained high postpartum. No change in TNF-α could be seen with advancing gestational age or postpartum. The PGF metabolite levels increased throughout pregnancy and decreased postpartum (IV).

In conclusion, normal pregnancy is associated with mild oxidative stress and inflammation. This might have physiological effects for normal pregnancy development. By delineating how these mediators of oxidative stress, angiogenesis and inflammation fluctuate throughout normal pregnancy and postpartum, we have established a reference for studies of these factors in pregnancy complications.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2012. 63 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 753
Keyword
Angiogenesis, inflammation, IL-6, F2-isoprostanes, oxidative stress, Pentraxin 3, PGF2α, PlGF, pregnancy, sFlt1, TNF-α, VEGF-A
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology; Medical Science
Identifiers
urn:nbn:se:uu:diva-171165 (URN)978-91-554-8314-2 (ISBN)
Public defence
2012-05-04, Brömssalen, entrance 11, Gävle Sjukhus, Gävle, 13:15 (Swedish)
Opponent
Supervisors
Available from: 2012-04-23 Created: 2012-03-15 Last updated: 2012-08-01Bibliographically approved

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Larsson, AndersPalm, MariaHelmersson, JohannaAxelsson, Ove

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