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Low calcitonin receptor like receptor expression in endometrial vessels from women with unexplained infertility.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Department of Obstetrics and Gynecology, Hospital Attached to Ningxia Medical College, Ningxia, China.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Stockholm, Sweden. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
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2011 (English)In: Gynecological Endocrinology, ISSN 0951-3590, E-ISSN 1473-0766, Vol. 27, no 9, 655-660 p.Article in journal (Refereed) Published
Abstract [en]

Adrenomedullin (AM) and its receptor subunit, calcitonin receptor-like receptor (CLR) are known to be important for endothelial function. The genotypes and phenotypes of AM and CLR in the endometrium were studied in relation to unexplained infertility. Endometrial biopsies from 12 fertile and 11 infertile women and blood samples from 156 fertile and 106 infertile women were collected. Protein and mRNA expression of AM and CLR was determined using immunohistochemistry and real time PCR. Allele and genotype frequencies in the AM (rs4399321 and rs7944706) and CLR genes (rs696574, rs1528233 and rs3771073) were performed using Taqman genotyping assays. Unexplained infertility was characterised by lower number of vessels stained with CLR in endometrium compared to fertile controls. There was no difference in AM expression. This could not be explained by SNP analysis in the AM or CLR genes. Imbalance in the AM/CLR system might alter endothelial function in women with unexplained infertility.

Place, publisher, year, edition, pages
2011. Vol. 27, no 9, 655-660 p.
Keyword [en]
Adrenomedullin, unexplained infertility, calcitonin receptor-like receptor, polymorphism
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-132606DOI: 10.3109/09513590.2010.521264ISI: 000293599900009PubMedID: 20954838OAI: oai:DiVA.org:uu-132606DiVA: diva2:358474
Available from: 2010-10-22 Created: 2010-10-22 Last updated: 2017-12-12Bibliographically approved

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Stavreus-Evers, AnneliKallak, Theodora Kunovac

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