Approaches to simultaneous analysis of frequency and severity of symptoms
2010 (English)In: Clinical Pharmacology and Therapeutics, ISSN 0009-9236, E-ISSN 1532-6519, Vol. 88, no 2, 255-259 p.Article in journal (Refereed) Published
Mechanistic models that synthesize pharmacological and (patho) physiological process information provide a rich basis for the characterization of drug action. However, the underlying clinical data are often simplified in a manner that does not allow models to fully elucidate the structure of the drug effect. In this article, we describe data-simplification strategies that are in routine use to describe disease symptoms and compare them with a model developed for handling the true complexities of the data.
Place, publisher, year, edition, pages
2010. Vol. 88, no 2, 255-259 p.
IdentifiersURN: urn:nbn:se:uu:diva-132773DOI: 10.1038/clpt.2010.118ISI: 000280147500025PubMedID: 20613722OAI: oai:DiVA.org:uu-132773DiVA: diva2:359125