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Brachial artery hyperemic blood flow velocity and left ventricular geometry
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (PIVUS /Lars Lind)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (PIVUS)
(English)In: Journal of Human Hypertension, ISSN 0950-9240, E-ISSN 1476-5527Article in journal (Other academic) Submitted
Abstract [en]

ABSTRACT

OBJECTIVE

Cardiovascular risk factors and carotid atherosclerosis relates to blood flow velocity in the brachial artery during induced hyperemia. This relation proved to be particularly strong when using the hyperemic systolic to diastolic blood flow velocity (SDFV) ratio. In this study, we further investigated this ratios value as a marker of vascular risk in relation to left ventricular (LV) geometry.

MATERIAL AND METHODS

In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, 1016 70-year-olds participated. Blood flow velocity during hyperemia of the brachial artery by Doppler was analysed. Echocardiography was performed, allowing analysis of LV geometry, categorised into four different groups: normal, concentric remodeling, concentric- and eccentric- hypertrophy.

RESULTS                                                                                                                                    

The SDFV ratio was increased in subjects with concentric LV -remodeling (p=0.006) or -hypertrophy (p=0.001), but not in those with eccentric hypertrophy (p=0.12) when compared to the group with normal LV geometry. These associations remained significant after adjustment for gender, blood pressure, blood glucose, body mass index and antihypertensive treatment.

CONCLUSION

The hyperemic systolic to diastolic blood flow velocity ratio in the brachial artery was related to concentric geometry of the LV in an elderly population sample, suggesting this new hemodynamic variable as a marker of increased afterload.

Keyword [en]
brachial blood flow velocity left ventricular geometry
National Category
Cardiac and Cardiovascular Systems
Research subject
Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-132916OAI: oai:DiVA.org:uu-132916DiVA: diva2:359634
Projects
PIVUS studien
Available from: 2010-10-28 Created: 2010-10-28 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Hyperemic Brachial Artery Blood Flow Velocity
Open this publication in new window or tab >>Hyperemic Brachial Artery Blood Flow Velocity
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis aims to evaluate the blood flow velocity in the Brachial artery during reactive hyperemia. Primarily to appraise the information it might contain regarding cardiovascular function and cardiovascular risk.

Ultrasonographic doppler measurements of the Brachial artery were made on the 1016 men and women aged 70 included in the prospective investigation of the vasculature in Uppsala seniors (PIVUS) study. Analysis of the blood flow velocity in the forearm was made in comparison to established methods of estimating endothelial function, clinical markers of cardiovascular risk, the Framingham risk score and global atherosclerosis determined by whole body magnetic resonance angiography.

Systolic blood flow velocity was positively related to cardiovascular risk whereas the diastolic velocity was inversely correlated. However, the systolic to diastolic blood flow velocity (SDFV) ratio was more closely associated with cardiovascular risk than its components apart.

Ultrasonographic markers of Carotid atherosclerosis were related to the SDFV ratio. Concentric left ventricular remodeling and left ventricular mass index were also associated with the SDFV ratio, but not to its numerator or denominator separately. A similar pattern was found when assessing SDFV ratio in relation to global atherosclerosis, as well as to established markers of arterial compliance and vasodilation.

In conclusion, during reactive hyperemia of the Brachial artery, the systolic to diastolic blood flow velocity ratio appears to contain information of additional value than its components separately, independently of established cardiovascular risk factors. Possibly, the SDFV ratio could offer a promising means to estimate cardiovascular risk in aging populations.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2010. 79 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 620
National Category
Medical and Health Sciences Cardiac and Cardiovascular Systems
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-132918 (URN)978-91-554-7942-8 (ISBN)
Public defence
2010-12-15, Enghoffsalen, Ingång 50, Akademiska Sjukhuset, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Projects
PIVUS
Available from: 2010-11-24 Created: 2010-10-28 Last updated: 2011-01-13Bibliographically approved

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Järhult, Susann J.

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