Brachial artery hyperemic blood flow velocity and left ventricular geometry
(English)In: Journal of Human Hypertension, ISSN 0950-9240, E-ISSN 1476-5527Article in journal (Other academic) Submitted
Cardiovascular risk factors and carotid atherosclerosis relates to blood flow velocity in the brachial artery during induced hyperemia. This relation proved to be particularly strong when using the hyperemic systolic to diastolic blood flow velocity (SDFV) ratio. In this study, we further investigated this ratios value as a marker of vascular risk in relation to left ventricular (LV) geometry.
MATERIAL AND METHODS
In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, 1016 70-year-olds participated. Blood flow velocity during hyperemia of the brachial artery by Doppler was analysed. Echocardiography was performed, allowing analysis of LV geometry, categorised into four different groups: normal, concentric remodeling, concentric- and eccentric- hypertrophy.
The SDFV ratio was increased in subjects with concentric LV -remodeling (p=0.006) or -hypertrophy (p=0.001), but not in those with eccentric hypertrophy (p=0.12) when compared to the group with normal LV geometry. These associations remained significant after adjustment for gender, blood pressure, blood glucose, body mass index and antihypertensive treatment.
The hyperemic systolic to diastolic blood flow velocity ratio in the brachial artery was related to concentric geometry of the LV in an elderly population sample, suggesting this new hemodynamic variable as a marker of increased afterload.
brachial blood flow velocity left ventricular geometry
Cardiac and Cardiovascular Systems
Research subject Medical Science
IdentifiersURN: urn:nbn:se:uu:diva-132916OAI: oai:DiVA.org:uu-132916DiVA: diva2:359634