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Studies of early growth mechanisms of hydroxyapatite on single crystalline rutile: a model system for bioactive surfaces
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden.
Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in Medicine)
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2010 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 21, no 10, 2743-2749 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies have shown that crystalline titanium oxide is in vitro bioactive and that there are differences in the HA formation mechanism depending on the crystalline direction of the titanium oxide surface. In the present study, the early adsorption of calcium and phosphate ions on three different surface directions of the single-crystal rutile TiO2 substrate has been investigated. A crucial step in the nucleation of HA is believed to be the adsorption of Ca2+ and PO4 3− from phosphate buffer solutions. The (001), (100) and (110) single crystalline rutile surfaces were soaked in phosphate buffer saline solution for 10 min, 1 h and 24 h at 37°C. The surfaces were then analyzed using time-of-flight secondary ion mass spectrometry (TOF-SIMS) and X-ray photoelectron spectroscopy (XPS). The results show that the adsorption of Ca2+ and PO4 3− is faster on the (001) and (100) surfaces than on the (110) surface. This study also shows that TOF-SIMS can be used as a tool to better understand the adsorption of calcium and phosphate ions and the growth mechanism of HA. This knowledge could be used to tailor new bioactive surfaces for better biological reaction.

Place, publisher, year, edition, pages
2010. Vol. 21, no 10, 2743-2749 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-133419DOI: 10.1007/s10856-010-4137-yISI: 000283371200004OAI: oai:DiVA.org:uu-133419DiVA: diva2:369314
Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials
Open this publication in new window or tab >>Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The clinical success of a bone-anchored implant is controlled by many factors such as implant shape, chemical composition, mechanical and surface properties. The surface properties (e.g. charge, wettability and roughness) are considered to be important parameters for the biological acceptance of the biomaterial, whereas the bulk properties control the biomechanical behaviour. For implants designed to be used in load-bearing applications in the skeletal system, the biomaterial should preferably integrate into bone tissue for a long lasting function. Lack of integration between the implant and bone increases the risk of micromotions, infections, soft tissue encapsulation, which all reduces the survival rate of the implant and makes revision surgery necessary. Coatings and surface modifications can be used to tailor properties of implant surfaces, and further improve the potential bone bonding and bone in-growth, compared to unmodified surfaces. A biomimetic method, developed by Kokubo, can be used to prepare a hydroxyapatite coating on to titanium substrates. The method is based on a solution based process where the compositions of the soaking medium and thus the formed coatings can be controlled. In this thesis, titanium (oxide) surfaces have been tailored via deposition of ion substituted hydroxyapatite coatings. Biologically relevant ions like strontium, silicon and fluoride were incorporated into apatite coatings. The substrates included well-defined rutile single crystals, as well as poly-crystalline titanium oxide surfaces and experimental Ti implants. The results showed that incorporation of substitute ions alters the morphology, crystallinity, composition and dissolution rates of apatite coatings. The in vivo effects of the ion substituted apatite coatings were also studied. The results showed that the ion substituted apatite coatings have good biocompatibility and can promote early bone formation.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2012. 57 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 986
National Category
Bio Materials
Research subject
Materials Science
Identifiers
urn:nbn:se:uu:diva-183345 (URN)978-91-554-8510-8 (ISBN)
Public defence
2012-12-06, Polacksbacken 2146, Ångströmslaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (Swedish)
Opponent
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Available from: 2012-11-16 Created: 2012-10-24 Last updated: 2013-01-23Bibliographically approved

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Lindahl, CarlXia, WeiEngqvist, Håkan

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