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Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction & Behaviour)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction & Behaviour)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction & Behaviour)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
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2010 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 117, no 9, 1077-1081 p.Article in journal (Refereed) Published
Abstract [en]

Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2beta. In the present study, we investigated TFAP-2beta protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2beta levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption. Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats.

Place, publisher, year, edition, pages
2010. Vol. 117, no 9, 1077-1081 p.
Keyword [en]
AA (alko, alcohol) rats, ANA (alko, non-alcohol) rats, Early-life experience, Free-choice drinking paradigm, Handling, Maternal separation
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-133567DOI: 10.1007/s00702-010-0448-xISI: 000281397200006PubMedID: 20690033OAI: oai:DiVA.org:uu-133567DiVA: diva2:369588
Available from: 2010-11-11 Created: 2010-11-11 Last updated: 2017-12-12Bibliographically approved

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Nylander, Ingrid

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