Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?
2010 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 117, no 9, 1077-1081 p.Article in journal (Refereed) Published
Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2beta. In the present study, we investigated TFAP-2beta protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2beta levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption. Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats.
Place, publisher, year, edition, pages
2010. Vol. 117, no 9, 1077-1081 p.
AA (alko, alcohol) rats, ANA (alko, non-alcohol) rats, Early-life experience, Free-choice drinking paradigm, Handling, Maternal separation
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-133567DOI: 10.1007/s00702-010-0448-xISI: 000281397200006PubMedID: 20690033OAI: oai:DiVA.org:uu-133567DiVA: diva2:369588