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The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. (Molekylär geriatrik)
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2010 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, Vol. 22, no 1, 247-255 p.Article in journal (Refereed) Published
Abstract [en]

The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.

Place, publisher, year, edition, pages
2010. Vol. 22, no 1, 247-255 p.
Keyword [en]
Age at onset, Alzheimer's disease, apolipoprotein E, CALHM1, polymorphism
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-133613DOI: 10.3233/JAD-2010-100933ISI: 000283294100021PubMedID: 20847397OAI: oai:DiVA.org:uu-133613DiVA: diva2:369915
Available from: 2010-11-12 Created: 2010-11-11 Last updated: 2011-03-08Bibliographically approved

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Ingelsson, MartinGiedraitis, VilmantasLannfelt, Lars
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