The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study
2010 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, Vol. 22, no 1, 247-255 p.Article in journal (Refereed) Published
The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.
Place, publisher, year, edition, pages
2010. Vol. 22, no 1, 247-255 p.
Age at onset, Alzheimer's disease, apolipoprotein E, CALHM1, polymorphism
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-133613DOI: 10.3233/JAD-2010-100933ISI: 000283294100021PubMedID: 20847397OAI: oai:DiVA.org:uu-133613DiVA: diva2:369915