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Bioactive glass scaffold with similar structure and mechanical properties of cancellous bone
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
2010 (English)In: Journal of biomedical materials research. Part B, Applied biomaterials, ISSN 1552-4973, Vol. 95B, no 2, 449-455 p.Article in journal (Refereed) Published
Abstract [en]

Natural bone is an amazing material because of its structure and mechanics. It is a challenge to find a bone substituted material mimicking natural bone intended to suffice for the need for bone repair and regeneration. In this study, a biomorphic material with similar structure and mechanical properties of cancellous bone has been fabricated by using demineralized cancellous bone as a template. Well-oriented particles in the pore walls could be observed clearly. The compressive strength of this scaffold was up to about 4.9 +/- 0.2MPa, close to the lower limit of the natural bone and 30 times of bioactive glass scaffolds, even though the porosity was up to 90%. This kind of bioactive glass composite scaffolds presented high resistance to deformation and showed an excellent shape restoration property. It is very close to a natural cancellous bone with a similar macro- and micro-structure and force-extension behavior. These results suggested this material would have a good potential in bone tissue engineering. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 95B: 449-455, 2010.

Place, publisher, year, edition, pages
2010. Vol. 95B, no 2, 449-455 p.
Keyword [en]
biomorphic, cancellous bone, scaffold, shape memory, bioactive glass
National Category
Medical and Health Sciences Engineering and Technology
URN: urn:nbn:se:uu:diva-133609DOI: 10.1002/jbm.b.31736ISI: 000283103400025OAI: oai:DiVA.org:uu-133609DiVA: diva2:369977
Available from: 2010-11-12 Created: 2010-11-11 Last updated: 2014-12-11Bibliographically approved

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