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High incidence of iron depletion and restless leg syndrome (RLS) in regular blood donors: intravenous iron sucrose substitution more effective than oral iron
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology and Transfusion Medicine.
2010 (English)In: Vox Sanguinis, ISSN 0042-9007, E-ISSN 1423-0410, Vol. 99, no 4, 354-361 p.Article in journal (Refereed) Published
Abstract [en]

Background and objectives Iron depletion is common in regular blood donors. The objective of the study was to investigate the frequency and severity of iron depletion in regular blood donors and whether IV iron is more effective than oral to avoid iron depletion and symptoms thereof, especially restless legs syndrome (RLS). Method One hundred and twenty blood donors with at least five previous whole blood donations were randomized to receive either IV iron sucrose (Venofer (R), RenaPharma/Vifor, Uppsala, Sweden), 200 mg, or to 20 x 100 mg of oral iron sulphate (Duroferon (R), GlaxoSmithKline, Stockholm, Sweden), after each blood donation during 1 year. Iron status and RLS incidence and severity were investigated. Results Iron status was generally poor among regular blood donors, especially in women, with a high incidence of iron depletion (> 20%) and RLS (18%). The IV iron group increased storage iron to a greater extent than the oral iron group after 12 months (P = 0 center dot 0043). Female donors were more responsive to IV iron sucrose compared to oral iron sulphate, particularly female donors below 50 years of age. RLS severity scores were significantly lower in the IV iron group. The two treatments were safe. Conclusion Iron status is poor in regular blood donors, restless legs syndrome is common, and the routine iron supplementation is insufficient. IV iron sucrose substitutes iron loss in blood donors more efficiently compared with oral iron sulphate, especially in women. Iron substitution to blood donors should be individualized and based on P-ferritin monitoring.

Place, publisher, year, edition, pages
2010. Vol. 99, no 4, 354-361 p.
Keyword [en]
blood donation, intravenous iron sucrose, iron deficiency, oral iron sulphate, restless legs syndrome
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-133576DOI: 10.1111/j.1423-0410.2010.01368.xISI: 000283091600008OAI: oai:DiVA.org:uu-133576DiVA: diva2:370354
Available from: 2010-11-16 Created: 2010-11-11 Last updated: 2010-11-16Bibliographically approved

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