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Autoantibodies to cardiac troponin in acute coronary syndromes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
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2010 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 411, no 21-22, 1793-1798 p.Article in journal (Refereed) Published
Abstract [en]

Backgrounds In a recent small study, patients with autoantibodies to cardiac troponin (cTnaAb) had higher cardiac troponin 1 (cTnl) release during an episode of acute coronary syndrome (ACS) than patients without cTnaAb and continued to have higher long-term levels of cTnl However, the prognostic importance of the occurrence of cTnaAb is unknown Methods In 957 nonST-elevation ACS patients cTnaAb and cTnl were analyzed at randomization and after 6 months. Outcomes were assessed through 5 years Results. Seven and 11% of the patients were cTnaAb positive at inclusion and 6 months, respectively The cardiac troponin I (cTnl) concentration at inclusion was independently associated with the development of cTnaAb (OR 1 53, 95% Cl 1 25-1 88) The presence of cTnaAb was associated with an increased cTnl level at 6 months (OR 2 39, 95% CI 1 50-381) cTnaAb was not independently associated with death and AMI during follow-up (HR 0 97. 95% Cl 0.61-1 54) Conclusion Development of cTnaAb after an episode of nonST-elevation ACS is associated with the acute myocardial damage, but occurs only in a minority of patients Furthermore, the presence of cTnaAb is associated with chronically elevated cTnl concentrations However, the occurrence of cTnaAb is not associated with an adverse long-term prognosis.

Place, publisher, year, edition, pages
2010. Vol. 411, no 21-22, 1793-1798 p.
Keyword [en]
Myocardial infarction, Troponin l, Antibodies, Diagnosis, Prognosis
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-133745DOI: 10.1016/j.cca.2010.08.005ISI: 000282562200042OAI: oai:DiVA.org:uu-133745DiVA: diva2:370479
Available from: 2010-11-16 Created: 2010-11-15 Last updated: 2017-12-12Bibliographically approved

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Lindahl, BertilEggers, Kai M.Gedeborg, Rolf

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