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Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
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2010 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 67, no 24, 4249-4256 p.Article in journal (Refereed) Published
Abstract [en]

Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.

Place, publisher, year, edition, pages
2010. Vol. 67, no 24, 4249-4256 p.
Keyword [en]
EBV, VDR, Transcription regulation, EBNA, Vitamin D3
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-133959DOI: 10.1007/s00018-010-0441-4ISI: 000284270000008PubMedID: 20593215OAI: oai:DiVA.org:uu-133959DiVA: diva2:371248
Available from: 2010-11-19 Created: 2010-11-19 Last updated: 2011-02-24Bibliographically approved

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