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The Effect of Voluntarily Ingested Buprenorphine on Rats Subjected to Surgically Induced Global Cerebral Ischaemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
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2010 (English)In: In Vivo, ISSN 0258-851X, Vol. 24, no 5, 641-646 p.Article in journal (Refereed) Published
Abstract [en]

The effect of perioperatively administered buprenorphine analgesia on rats subjected to surgically induced global ischaemia was assessed. Rats supplied with buprenorphine, mixed in nut paste for voluntary ingestion, displayed significant reductions in postoperative excretions of faecal corticosterone, in both magnitude and variance. This is indicative of lowered stress levels and less inter-animal metabolic variation. Although corticosterone has been reported to modulate the extent of cerebral damage, histology of coronal sections exhibited no differences in the extent of the ischaemia in buprenorphine-treated and untreated animals. A part from a slightly higher hyperthermia immediately after surgery and typical opiate-associated behaviour, the buprenorphine treatment had no apparent adverse effects on the experimental model. In contrast, the analgesic treatment improved the model by minimizing stress-associated confounding variables in the experimental animals.

Place, publisher, year, edition, pages
2010. Vol. 24, no 5, 641-646 p.
Keyword [en]
Analgesia, buprenorphine, corticosterone, cerebral ischaemia, refinement
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-133810ISI: 000283400500004OAI: oai:DiVA.org:uu-133810DiVA: diva2:371600
Available from: 2010-11-22 Created: 2010-11-16 Last updated: 2010-11-22Bibliographically approved

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