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Electrochemical impedance spectroscopy in label-free biosensor applications: multivariate data analysis for an objective interpretation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2010 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 398, no 6, 2341-2349 p.Article, review/survey (Refereed) Published
Abstract [en]

Electrochemical impedance spectroscopy plays an important role in biosensor science thanks to the possibility of finding specific information from processes with different kinetics at a chosen electrode potential in one experiment. In this paper we briefly discuss label-free impedimetric biosensors described in the literature. A novel method for neutral interpretation of impedance data is presented that includes complex number chemometrics. Three examples are given based on impedance measurements on synthetic biomembranes, in this case a lipid monolayer deposited on a mercury electrode. The interaction of various compounds with the monomolecular lipid layer is illustrated with the following: (1) different concentrations of magainin (Geladi et al. in Proc. Int. Fed. Med. Biomed. Eng. 9:219-220, 2005); (2) different derivatives of gramicidin A (Lindholm-Sethson et al. in Langmuir 24:5029-5032, 2007), and (3) an antimicrobial peptide (Ringstad et al. in Langmuir 24:208-216, 2008).

Place, publisher, year, edition, pages
2010. Vol. 398, no 6, 2341-2349 p.
Keyword [en]
Impedance, Biosensor, Complex number chemometrics
National Category
Pharmaceutical Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-134129DOI: 10.1007/s00216-010-4027-7ISI: 000283588600002OAI: oai:DiVA.org:uu-134129DiVA: diva2:371613
Available from: 2010-11-22 Created: 2010-11-22 Last updated: 2017-12-12Bibliographically approved

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