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Vitamin D, light and mental health
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2010 (English)In: Journal of Photochemistry and Photobiology. B: Biology, ISSN 1011-1344, E-ISSN 1873-2682, Vol. 101, no 2, 142-149 p.Article in journal (Refereed) Published
Abstract [en]

Vitamin D receptors and vitamin D metabolizing enzymes are present in the central nervous system. Calcitriol (the active vitamin D hormone) affects numerous neurotransmitters and neurotrophic factors, relevant for mental disorders. In the case of depressive disorders, considerable evidence supports a role of suboptimal vitamin D levels. However, the data are not conclusive and further studies are necessary. Especially, the relative importance o/f the pineal-melatonin system versus the vitamin D-endocrine system for the pathogenesis of seasonal affective disorders is presently unresolved. Two diagnoses, schizophrenia and autism, have been hypothetically linked to developmental (prenatal) vitamin D deficiency, however, also in adult patients, low levels have been reported, supporting the notion that vitamin D deficiency may not only be a predisposing developmental factor but also relate to the adult patients' psychiatric state. Two cases are described, whose psychiatric improvement coincided with effective treatment of vitamin D deficiency.

Place, publisher, year, edition, pages
2010. Vol. 101, no 2, 142-149 p.
Keyword [en]
Vitamin D, Neurotrophic factors, Autism, Schizophrenia, Depressive disorders, Phototherapy
National Category
Medical and Health Sciences Biological Sciences
URN: urn:nbn:se:uu:diva-134357DOI: 10.1016/j.jphotobiol.2010.08.003ISI: 000282623600007OAI: oai:DiVA.org:uu-134357DiVA: diva2:372313
Available from: 2010-11-25 Created: 2010-11-24 Last updated: 2010-11-25Bibliographically approved

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Psychiatry, University Hospital
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