uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Recent trends in primary antimicrobial resistance of Helicobacter pylori in Finland
Show others and affiliations
2011 (English)In: International Journal of Antimicrobial Agents, ISSN 0924-8579, E-ISSN 1872-7913, Vol. 37, no 1, 22-25 p.Article in journal (Refereed) Published
Abstract [en]

The antimicrobial susceptibility of Helicobacter pylori is an important predictor of the success of eradication therapy. To evaluate recent changes in primary antimicrobial resistance of H. pylori isolated from Finnish patients, the clinical records of H. pylori-positive patients referred for endoscopy to Herttoniemi Hospital (Helsinki, Finland) during 2000-2008 were investigated retrospectively. Stored H. pylori strains from 505 patients without previous eradication therapy were tested for clarithromycin, metronidazole, levofloxacin, tetracycline and amoxicillin susceptibility by Etest. Data on local consumption of antimicrobials were collected and correlations between consumption and resistance were calculated. During the 9-year study period, metronidazole resistance was high (range 29-59%, overall 41%). After an initial increase in clarithromycin resistance (0% in 2000 to 16% in 2003), resistance to clarithromycin decreased to 4% in 2008. No significant correlation was detected between consumption of macrolides and resistance of clarithromycin. Resistance to levofloxacin varied between 0% and 12%. Primary metronidazole resistance in H. pylori is at a high level, however levofloxacin and clarithromycin resistances are still at a reasonable level. Thus, primary clarithromycin resistance in H. pylori in Finland has not become such a problem as in many other countries. Primary resistance to the antimicrobials studied varied considerably from year to year.

Place, publisher, year, edition, pages
2011. Vol. 37, no 1, 22-25 p.
Keyword [en]
Antibacterial agents, Drug resistance, Helicobacter pylori, Microbial
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-134423DOI: 10.1016/j.ijantimicag.2010.09.013ISI: 000285332700005PubMedID: 21084175OAI: oai:DiVA.org:uu-134423DiVA: diva2:372482
Available from: 2010-11-25 Created: 2010-11-25 Last updated: 2011-01-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Medical Sciences
In the same journal
International Journal of Antimicrobial Agents
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 140 hits
ReferencesLink to record
Permanent link

Direct link