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Changes of Surface Composition and Morphology after Incorporation of Ions into Biomimetic Apatite Coating
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
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2010 (English)In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 1, no 1, 7-16 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2010. Vol. 1, no 1, 7-16 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-134454DOI: 10.4236/jbnb.2010.11002OAI: oai:DiVA.org:uu-134454DiVA: diva2:372553
Available from: 2010-11-26 Created: 2010-11-26 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials
Open this publication in new window or tab >>Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The clinical success of a bone-anchored implant is controlled by many factors such as implant shape, chemical composition, mechanical and surface properties. The surface properties (e.g. charge, wettability and roughness) are considered to be important parameters for the biological acceptance of the biomaterial, whereas the bulk properties control the biomechanical behaviour. For implants designed to be used in load-bearing applications in the skeletal system, the biomaterial should preferably integrate into bone tissue for a long lasting function. Lack of integration between the implant and bone increases the risk of micromotions, infections, soft tissue encapsulation, which all reduces the survival rate of the implant and makes revision surgery necessary. Coatings and surface modifications can be used to tailor properties of implant surfaces, and further improve the potential bone bonding and bone in-growth, compared to unmodified surfaces. A biomimetic method, developed by Kokubo, can be used to prepare a hydroxyapatite coating on to titanium substrates. The method is based on a solution based process where the compositions of the soaking medium and thus the formed coatings can be controlled. In this thesis, titanium (oxide) surfaces have been tailored via deposition of ion substituted hydroxyapatite coatings. Biologically relevant ions like strontium, silicon and fluoride were incorporated into apatite coatings. The substrates included well-defined rutile single crystals, as well as poly-crystalline titanium oxide surfaces and experimental Ti implants. The results showed that incorporation of substitute ions alters the morphology, crystallinity, composition and dissolution rates of apatite coatings. The in vivo effects of the ion substituted apatite coatings were also studied. The results showed that the ion substituted apatite coatings have good biocompatibility and can promote early bone formation.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2012. 57 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 986
National Category
Bio Materials
Research subject
Materials Science
Identifiers
urn:nbn:se:uu:diva-183345 (URN)978-91-554-8510-8 (ISBN)
Public defence
2012-12-06, Polacksbacken 2146, Ångströmslaboratoriet, Lägerhyddsvägen 1, Uppsala, 10:15 (Swedish)
Opponent
Supervisors
Available from: 2012-11-16 Created: 2012-10-24 Last updated: 2013-01-23Bibliographically approved

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Xia, WeiLindahl, CarlPersson, CeciliaEngqvist, Håkan

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