uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The epidemiology and clinical features of portal vein thrombosis: a multicentre study
Show others and affiliations
2010 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 32, no 9, 1154-1162 p.Article in journal (Refereed) Published
Abstract [en]

Background Reliable epidemiological data for portal vein thrombosis are lacking. Aims To investigate the incidence, prevalence and survival rates for patients with portal vein thrombosis. Methods Retrospective multicentre study of all patients registered with the diagnosis of portal vein thrombosis between 1995 and 2004. Results A total of 173 patients (median age 57 years, 93 men) with portal vein thrombosis were identified and followed up for a median of 2.5 years (range 0-9.7). The mean age-standardized incidence and prevalence rates were 0.7 per 100 000 per year and 3.7 per 100 000 inhabitants, respectively. Liver disease was present in 70 patients (40%), malignancy in 27%, thrombophilic factors in 22% and myeloproliferative disorders in 11%. Two or more risk factors were identified in 80 patients (46%). At diagnosis, 65% were put on anticoagulant therapy. Thrombolysis, TIPS, surgical shunting and liver transplantation were performed in 6, 3, 2 and 8 patients, respectively. The overall survival at 1 year and 5 years was 69% and 54%. In the absence of malignancy and cirrhosis, the survival was 92% and 76%, respectively. Conclusions The incidence and prevalence rates of portal vein thrombosis were 0.7 per 100 000 inhabitants per year and 3.7 per 100 000 inhabitants, respectively. Concurrent prothrombotic risk factors are common. The prognosis is variable and highly dependent on underlying disease.

Place, publisher, year, edition, pages
2010. Vol. 32, no 9, 1154-1162 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-134652DOI: 10.1111/j.1365-2036.2010.04454.xISI: 000282570800012OAI: oai:DiVA.org:uu-134652DiVA: diva2:373830
Available from: 2010-12-01 Created: 2010-11-30 Last updated: 2010-12-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Medical Sciences
In the same journal
Alimentary Pharmacology and Therapeutics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 158 hits
ReferencesLink to record
Permanent link

Direct link