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Motor Unit Number Index (MUNIX): A novel neurophysiological technique to follow disease progression in amyotrophic lateral sclerosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
2010 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 42, no 3, 379-384 p.Article in journal (Refereed) Published
Abstract [en]

Motor unit number estimation techniques in amyotrophic lateral sclerosis (ALS) patients are technically challenging and time-consuming. The Motor Unit Number Index (MUNIX) is a novel technique based on surface-EMG recordings and requires only 3-5 minutes per muscle. The objective was to explore the feasibility of longitudinal MUNIX measurements in ALS patients. In seven patients enrolled in a clinical trial, eight muscles were studied every 2 months for up to 15 months in addition to the revised ALS-functional rating scale, slow vital capacity, and compound muscle action potentials. The method was well tolerated and easy to perform. Initial MUNIX measures were significantly reduced compared to controls (487 +/- 194 vs. 1459 113; P < 0.001). Relative drop from baseline paralleled the clinical course and was greater than the drop of other markers of disease progression. MUNIX measurements in multiple muscles are suitable for serial neurophysiologic investigations in ALS. Further longitudinal data are needed for reliability validation.

Place, publisher, year, edition, pages
2010. Vol. 42, no 3, 379-384 p.
Keyword [en]
MUNIX, MUNE, amyotrophic lateral sclerosis, neurophysiology, marker of disease progression
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-134908DOI: 10.1002/mus.21707ISI: 000281627400010PubMedID: 20589888OAI: oai:DiVA.org:uu-134908DiVA: diva2:374036
Available from: 2010-12-02 Created: 2010-12-02 Last updated: 2010-12-02Bibliographically approved

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