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Single-shot femtosecond x-ray diffraction from randomly oriented ellipsoidal nanoparticles
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2010 (English)In: Physical Review Special Topics. Accelerators and Beams, ISSN 1098-4402, E-ISSN 1098-4402, Vol. 13, no 9, 094701- p.Article in journal (Refereed) Published
Abstract [en]

Coherent diffractive imaging of single particles using the single-shot "diffract and destroy" approach with an x-ray free electron laser (FEL) was recently demonstrated. A high-resolution low-noise coherent diffraction pattern, representative of the object before it turns into a plasma and explodes, results from the interaction of the FEL with the particle. Iterative phase retrieval algorithms are used to reconstruct two-dimensional projection images of the object from the recorded intensities alone. Here we describe the first single-shot diffraction data set that mimics the data proposed for obtaining 3D structure from identical particles. Ellipsoidal iron oxide nanoparticles (250 nm x 50 nm) were aerosolized and injected through an aerodynamic lens stack into a soft x-ray FEL. Particle orientation was not controlled with this injection method. We observed that, at the instant the x-ray pulse interacts with the particle, a snapshot of the particle's orientation is encoded in the diffraction pattern. The results give credence to one of the technical concepts of imaging individual nanometer and subnanometer-sized objects such as single molecules or larger clusters of molecules using hard x-ray FELs and will be used to help develop robust algorithms for determining particle orientations and 3D structure.

Place, publisher, year, edition, pages
2010. Vol. 13, no 9, 094701- p.
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-134893DOI: 10.1103/PhysRevSTAB.13.094701ISI: 000281869300002OAI: oai:DiVA.org:uu-134893DiVA: diva2:374082
Available from: 2010-12-02 Created: 2010-12-02 Last updated: 2017-12-12Bibliographically approved

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Seibert, Marvin M.Timneanu, Nicusor

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