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α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. (Functional Pharmacology/Funktionell Farmakologi)
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2010 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 31, no 11, 2141-2144 p.Article in journal (Refereed) Published
Abstract [en]

Interleukin-1 beta (IL-1β) significantly influences cognitive processes. Treatments which raise the level of IL-1β in the brain impair memory consolidation in contextual fear conditioning. However, the effect of IL-1β on memory reconsolidation has not yet been established. The melanocortin α-melanocyte-stimulating hormone (α-MSH) exerts potent anti-inflammatory actions by antagonizing the effect of proinflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, of which MC3R and MC4R are predominant in the central nervous system. The present experiments show that the injection of IL-1β (5 ng/0.25 μl) in dorsal hippocampus up to 30 min after re-exposition to the context decreases freezing during the contextual fear test. Impairment of memory reconsolidation was reversed by treatment with α-MSH (0.05 μg/0.25 μl). Administration of the MC4 receptor antagonist HS014 (0.5 μg/0.25 μl) blocked the effect of α-MSH. These results suggest that IL-1β may influence memory reconsolidation and that activation of central MC4R could lead to improve cognitive performance.

Place, publisher, year, edition, pages
2010. Vol. 31, no 11, 2141-2144 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135054DOI: 10.1016/j.peptides.2010.07.018ISI: 000284501800027PubMedID: 20688120OAI: oai:DiVA.org:uu-135054DiVA: diva2:374323
Available from: 2010-12-03 Created: 2010-12-03 Last updated: 2011-04-28Bibliographically approved

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