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Neuronal collagen XVII is localized to lipofuscin granules
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. (Alafuzoff)
2010 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 21, no 17, 1090-1094 p.Article in journal (Refereed) Published
Abstract [en]

We have earlier shown that collagen XVII is expressed by neurons in the human brain, although its exact intracellular location and function have remained unknown. In this study we have localized collagen XVII specifically to neuronal lipofuscin granules using electron microscopy in autopsy samples from the human brainstem. Our results show that collagen XVII expression is mainly confined to an ultrastructurally definable, specific type of lipofuscin granule. The function of neuronal collagen XVII remains unclear. However, as the functional significance of lipofuscin remains debated, the presence of collagen XVII in just some types of lipofuscin may be helpful in the process of exploring the variety of neuronal, age-related lipopigments, which are as yet defined operationally rather than functionally or structurally.

Place, publisher, year, edition, pages
2010. Vol. 21, no 17, 1090-1094 p.
Keyword [en]
brain, collagen XVII, lipofuscin
National Category
Clinical Laboratory Medicine
Research subject
URN: urn:nbn:se:uu:diva-134101DOI: 10.1097/WNR.0b013e3283405352ISI: 000283745400006PubMedID: 20926972OAI: oai:DiVA.org:uu-134101DiVA: diva2:374375
Available from: 2010-12-03 Created: 2010-11-22 Last updated: 2012-05-07Bibliographically approved

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