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Gastroesophageal reflux disease in children and adolescents in primary care
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
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2010 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, Vol. 45, no 2, 139-146 p.Article in journal (Refereed) Published
Abstract [en]

Objectives. To determine the prevalence and incidence of a diagnosis of gastroesophageal reflux disease (GERD) in children and adolescents in UK primary care, and to assess comorbidities that are associated with a diagnosis of GERD. Material and methods. Incident GERD cases during 2000-05 were identified from The Health Improvement Network (THIN) UK primary care database via a computer search for diagnostic codes for GERD, followed by manual review of the patient records. Results. We identified 1700 children with a first diagnosis of GERD during 2000-05. The incidence of GERD was 0.84 per 1000 person-years. The incidence decreased with age from 1.48 per 1000 person-years among 1-year-old children until the age of 12 years, whereupon it increased to a maximum at 16-17 years of 2.26 per 1000 person-years for girls and 1.75 per 1000 person-years for boys. Pregnant adolescents were not included in the study. In addition to typical GERD symptoms (epigastric pain, heartburn, reflux, regurgitation), 21.2% of children reported nausea or vomiting. Children with neurological disorders were at increased risk of a GERD diagnosis. Hiatus hernia and congenital esophageal disorders were also associated with a diagnosis of GERD. Children and adolescents using antiepileptics, oral/inhaled steroids, beta-agonists and paracetamol had an increased risk of a GERD diagnosis. Conclusions. The incidence of a GERD diagnosis was age-dependent and was highest among very young children and older female adolescents. Children with neurological impairments and other comorbidities were at increased risk of a GERD diagnosis.

Place, publisher, year, edition, pages
2010. Vol. 45, no 2, 139-146 p.
Keyword [en]
Epidemiology, gastroesophageal reflux disease, pediatric, primary care
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135130DOI: 10.3109/00365520903428606ISI: 000273874200003OAI: oai:DiVA.org:uu-135130DiVA: diva2:374477
Available from: 2010-12-04 Created: 2010-12-04 Last updated: 2011-08-15Bibliographically approved

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Wallander, Mari-Ann
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