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Postpartum depression symptoms: a case-control study on monoaminergic functional polymorphisms and environmental stressors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Reproduktiv hälsa/Sundström Poromaa)
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2011 (English)In: Psychiatric Genetics, ISSN 0955-8829, E-ISSN 1473-5873, Vol. 21, no 1, 19-28 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE:

Postpartum depression (PPD) is an under diagnosed and under treated mood disorder, with negative impact on both the mother and the infant's health. The aim of this study is to examine whether genetic variations in the monoaminergic neurotransmitter system, together with environmental stressors, contribute to the development of PPD symptoms.

METHODS:

This nested case-control study included 275 women from a population-based cohort of delivering women in Sweden. A questionnaire containing the Edinburgh Postnatal Depression Scale was collected at 6 weeks and 6 months postpartum. Three functional polymorphisms were genotyped, catechol-O-methyltransferase (COMT)-ValMet, monoamine oxidase A (MAOA)-upstream variable number tandem repeat (uVNTR) and serotonin transporter linked polymorphic region (5HTT-LPR). Stressful life events, maternity stressors and previous psychiatric contact were considered as potential risk factors.

RESULTS:

COMT-ValMet was significantly associated with PPD symptoms at 6 weeks, but not at 6 months postpartum. A significant gene-gene interaction effect was present between COMT-ValMet and MAOA-uVNTR. In a gene-environment multivariate model, COMT-ValMet, psychiatric contact and maternity stressors were significantly associated with PPD symptoms. Among those with history of psychiatric problems, the COMT-ValMet and 5HTT-LPR risk variants were associated with PPD symptoms, whereas in the absence of previous psychiatric contact only maternity stressors were related to PPD symptoms.

CONCLUSION:

The interaction effect between monoaminergic genes and environmental stressors is likely to contribute to vulnerability for PPD. The different patterns of association according to history of psychiatric problems, if replicated, might be helpful in screening strategies.

Place, publisher, year, edition, pages
2011. Vol. 21, no 1, 19-28 p.
Keyword [en]
catechol-O-methyltransferase, Edinburgh Postnatal Depression Scale, environment, gene, monoamine oxidase A, monoamines, postpartum depression, serotonin transporter, stressful life events
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-135161DOI: 10.1097/YPG.0b013e328341a3c1ISI: 000285544800004PubMedID: 21099450OAI: oai:DiVA.org:uu-135161DiVA: diva2:374596
Available from: 2010-12-06 Created: 2010-12-06 Last updated: 2017-12-12Bibliographically approved

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Comasco, ErikaSylvén, Sara MPapadopoulos, Fotios C.Sundström-Poromaa, IngerSkalkidou, Alkistis

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Comasco, ErikaSylvén, Sara MPapadopoulos, Fotios C.Sundström-Poromaa, IngerSkalkidou, Alkistis
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Centre for Clinical Research, County of VästmanlandPharmacologyDepartment of Women's and Children's HealthPsychiatry, University Hospital
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