uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Confirmed hypertension and plasma 25(OH)D concentrations amongst elderly men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Show others and affiliations
2011 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 269, no 2, 211-218 p.Article in journal (Refereed) Published
Abstract [en]


The results of experimental studies suggest that vitamin D deficiency activates the renin-angiotensin system and predisposes to hypertension. Results of previous epidemiological studies investigating the association between 25-hydroxyvitamin D [25(OH)D] status and hypertension have not been consistent, perhaps because of their sole reliance on office blood pressure (BP) measurements leading to some misclassification of hypertension status. No previous studies have examined the association between 25(OH)D status and confirmed hypertension assessed with both office and 24-h BP measurements.


In this cross-sectional study, we investigated 833 Caucasian men, aged 71 +/- 0.6 years, to determine the association between plasma 25(OH)D concentrations, measured with high-pressure liquid chromatography mass spectrometry, and the prevalence of hypertension. We used both supine office and 24-h BP measurements for classifying participants as normotensive or confirmed hypertensive; participants with inconsistent classifications were excluded.


In a multivariable adjusted logistic regression model, men with 25(OH)D concentrations < 37.5 nmol L-1 had a 3-fold higher prevalence of confirmed hypertension compared to those with >= 37.5 nmol L-1 25(OH)D (odds ratio = 3.3, 95% CI: 1.0-11.0).


Our results show that low plasma 25(OH)D concentration is associated with a higher prevalence of confirmed hypertension.

Place, publisher, year, edition, pages
2011. Vol. 269, no 2, 211-218 p.
Keyword [en]
25-hydroxyvitamin D concentrations, Blood pressure, Confirmed hypertension, Vitamin D
National Category
Medical and Health Sciences
Research subject
URN: urn:nbn:se:uu:diva-135226DOI: 10.1111/j.1365-2796.2010.02309.xISI: 000286110100010PubMedID: 21091810OAI: oai:DiVA.org:uu-135226DiVA: diva2:374746
Available from: 2010-12-06 Created: 2010-12-06 Last updated: 2016-01-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Byberg, LiisaSundström, JohanMelhus, HåkanMichaëlsson, Karl
By organisation
OrthopaedicsGeriatricsDepartment of Medical Sciences
In the same journal
Journal of Internal Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 222 hits
ReferencesLink to record
Permanent link

Direct link