uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
Show others and affiliations
2010 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 65, no 9, 1189-1195 p.Article in journal (Refereed) Published
Abstract [en]

Background: Allergen-specific IgE testing is often performed with crude peanut extract, but the results may be difficult to interpret because of cross-reactions between peanut and other plant allergens. The aim was to investigate IgE reactivity to peanut allergen components in children from a birch-rich region in relation to pollen sensitization and peanut symptoms. Methods: From a birth cohort, clinical parameters were obtained through questionnaires and IgE antibody levels to peanut and birch pollen were measured. Different peanut/birch sensitization phenotypes were defined among 200 selected children. IgE reactivity to peanut and pollen allergen components was analysed using microarray technique. Results: Peanut symptoms were reported in 87% of the children with IgE reactivity to any of the peanut allergens Ara h 1, 2 or 3 but not to Ara h 8 (n = 46) vs 17% of children with IgE reactivity to Ara h 8 but not to Ara h 1, 2 or 3 (n = 23), P < 0.001. Furthermore, symptoms were more severe in children with Ara h 1, 2 or 3 reactivity. Children with IgE reactivity both to Ara h 2 and to Ara h 1 or 3 more often reported peanut symptoms than children with IgE only to Ara h 2 (97% vs 70%, P = 0.016), particularly respiratory symptoms (50% vs 9%, P = 0.002). Conclusions: IgE analysis to peanut allergen components may be used to distinguish between peanut-sensitized individuals at risk of severe symptoms and those likely to have milder or no symptoms to peanut if sensitized to pollen allergens and their peanut homologue allergens.

Place, publisher, year, edition, pages
2010. Vol. 65, no 9, 1189-1195 p.
Keyword [en]
allergen components, BAMSE, childhood, IgE, peanut
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-134998DOI: 10.1111/j.1398-9995.2010.02334.xISI: 000280651000015OAI: oai:DiVA.org:uu-134998DiVA: diva2:374847
Available from: 2010-12-06 Created: 2010-12-03 Last updated: 2011-01-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Respiratory Medicine and Allergology
In the same journal
Allergy. European Journal of Allergy and Clinical Immunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 158 hits
ReferencesLink to record
Permanent link

Direct link