Serum and Cerebrospinal Fluid Levels of Colistin in Pediatric Patients
2010 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 54, no 9, 3985-3987 p.Article in journal (Refereed) Published
Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 11/2 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 mu g/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 mu g/ml but increased in the presence of meningitis (similar to 0.5 mu g/ml or 34 to 67% of serum levels).
Place, publisher, year, edition, pages
2010. Vol. 54, no 9, 3985-3987 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-135415DOI: 10.1128/AAC.01799-09ISI: 000281005900068OAI: oai:DiVA.org:uu-135415DiVA: diva2:375002