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Serum and Cerebrospinal Fluid Levels of Colistin in Pediatric Patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2010 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 54, no 9, 3985-3987 p.Article in journal (Refereed) Published
Abstract [en]

Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 11/2 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 mu g/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 mu g/ml but increased in the presence of meningitis (similar to 0.5 mu g/ml or 34 to 67% of serum levels).

Place, publisher, year, edition, pages
2010. Vol. 54, no 9, 3985-3987 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-135415DOI: 10.1128/AAC.01799-09ISI: 000281005900068OAI: oai:DiVA.org:uu-135415DiVA: diva2:375002
Available from: 2010-12-07 Created: 2010-12-06 Last updated: 2017-12-11Bibliographically approved

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