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A signal for an abuse liability for pregabalin-results from the Swedish spontaneous adverse drug reaction reporting system
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Pharmacology.
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2010 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 66, no 9, 947-953 p.Article in journal (Refereed) Published
Abstract [en]

Pregabalin is a gamma-aminobutyric acid (GABA) analogue approved for the treatment of epilepsy, neuropathic pain and generalised anxiety disorder. As a GABA analogue, there has been some concern about an abuse liability. We aimed to investigate the possible abuse liability of pregabalin. By applying a Bayesian data-mining algorithm to reports of possible drug abuse or addiction in the Swedish national register of adverse drug reactions (SWEDIS), we calculated the information component (IC) for pregabalin and reports of abuse and addiction. Out of 198 reports indicative of abuse or addiction to any drug, 16 concerned pregabalin. The IC became significantly elevated in the fourth quarter of 2008, rising to 3.99 (95% confidence interval 3.21-4.59) at the end of 2009. Based on the signal from the present study, we conclude that pregabalin is likely to be associated with an abuse potential.

Place, publisher, year, edition, pages
2010. Vol. 66, no 9, 947-953 p.
Keyword [en]
Pregabalin, Abuse, Addiction, Adverse drug reaction, Data-mining
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-134979DOI: 10.1007/s00228-010-0853-yISI: 000280922000013OAI: oai:DiVA.org:uu-134979DiVA: diva2:375003
Available from: 2010-12-07 Created: 2010-12-03 Last updated: 2017-12-11Bibliographically approved

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