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Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions
Department of Clinical Science/Obstetrics and Gynecology, Umeå University, Umeå, Sweden.
Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
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2010 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 202, no 1, 71.e1- p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: We sought to analyze the presence of the microorganisms Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus (HPV), and the polyomaviruses BK virus (BKV) and JC virus (JCV) in ovarian tissues of women with ovarian carcinomas, borderline tumors, and benign conditions. STUDY DESIGN: Ovarian tissue, snap-frozen and stored at -80 degrees C, from 186 women with benign conditions, borderline tumors, and epithelial ovarian cancer, as well as tissue from the contralateral ovary of 126 of these women, were analyzed regarding presence of C trachomatis and N gonorrhoeae (transcription mediated amplification), M genitalium (real-time polymerase chain reaction [PCR]), HPV (PCR), and BKV and JCV (PCR). RESULTS: All the tissue samples studied were found negative for the microorganisms analyzed. CONCLUSION: C trachomatis, M genitalium, N gonorrhoeae, HPV, and the polyomaviruses BKV and JCV are not detectable in ovarian tissues either from women with benign conditions and borderline tumors or from women with ovarian cancer.

Place, publisher, year, edition, pages
2010. Vol. 202, no 1, 71.e1- p.
Keyword [en]
bacteria, borderline ovarian tumors, infection, ovarian cancer, virus
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135465DOI: 10.1016/j.ajog.2009.07.042ISI: 000273026200020PubMedID: 19766974OAI: oai:DiVA.org:uu-135465DiVA: diva2:375083
Available from: 2010-12-07 Created: 2010-12-07 Last updated: 2010-12-20Bibliographically approved

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