Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
2010 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 42, no 8, 661-664 p.Article in journal (Refereed) Published
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
Place, publisher, year, edition, pages
2010. Vol. 42, no 8, 661-664 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-135598DOI: 10.1038/ng.626ISI: 000280524000008PubMedID: 20639881OAI: oai:DiVA.org:uu-135598DiVA: diva2:375248