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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
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2010 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 42, no 8, 661-664 p.Article in journal (Refereed) Published
Abstract [en]

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

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2010. Vol. 42, no 8, 661-664 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-135598DOI: 10.1038/ng.626ISI: 000280524000008PubMedID: 20639881OAI: oai:DiVA.org:uu-135598DiVA: diva2:375248
Available from: 2010-12-07 Created: 2010-12-07 Last updated: 2017-12-11Bibliographically approved

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