uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Decrease in Propagation of Interictal Epileptiform Activity After Introduction of Levetiracetam Visualized with Electric Source Imaging
Department of Neurosurgery, Oslo University Hospital, Norway.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnneurologisk forskning/Ahlsten)
Department of Neurology, University Hospital, Geneva, Switzerland.
Neurology Clinic, University Hospital, Geneva, Switzerland.
Show others and affiliations
2010 (English)In: Brain Topography, ISSN 0896-0267, E-ISSN 1573-6792, Vol. 23, no 3, 269-278 p.Article in journal (Refereed) Published
Abstract [en]

Different neuroimaging techniques (fMRI, spectroscopy, PET) are being used to evaluate candidate drugs in pharmacological development. In patients with epilepsy fast propagation of the epileptiform activity between different brain areas occurs. Electric Source Imaging (ESI), in contrast to the aforementioned techniques, has a millisecond time resolution, allowing visualization of this fast propagation. The purpose of the current project was to use ESI to investigate whether introduction of an antiepileptic drug (levetiracetam, LEV) would change the propagation patterns of the interictal epileptiform activity. Thirty patients with epilepsy were subject to an EEG recording before (pre-LEV) and after (in-LEV) introduction of LEV. Interictal spikes with similar topographic distribution were averaged within each subject, and a distributed source model was used to localize the EEG sources of the epileptiform activity. The temporal development of the activity within 20 regions of interest (ROIs) was determined, and source propagation between different regions was compared between the pre-LEV and in-LEV recordings. Patients with epileptic seizures showed propagation in 22/24 identified spike types in the pre-LEV recordings. In the in-LEV recordings only 7/15 spike types showed propagation, and six of these seven propagating spikes were recorded in patients with poor effect of treatment. Also in patients without seizures LEV tended to suppress propagation. We conclude that the observed suppression of source propagation can be considered as an indicator of effective antiepileptic treatment. ESI might thus become a useful tool in the early clinical evaluation of new candidate drugs in pharmacological development.

Place, publisher, year, edition, pages
2010. Vol. 23, no 3, 269-278 p.
Keyword [en]
EEG, Epilepsy, Electric source imaging, Propagation, Levetiracetam
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135610DOI: 10.1007/s10548-010-0150-1ISI: 000280619300005OAI: oai:DiVA.org:uu-135610DiVA: diva2:375293
Available from: 2010-12-07 Created: 2010-12-07 Last updated: 2011-01-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Eeg-Olofsson, Orvar
By organisation
Department of Women's and Children's Health
In the same journal
Brain Topography
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 154 hits
ReferencesLink to record
Permanent link

Direct link