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Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in Escherichia coli and Klebsiella spp. from Norway and Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
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2010 (English)In: Diagnostic microbiology and infectious disease, ISSN 0732-8893, E-ISSN 1879-0070, Vol. 66, no 4, 425-431 p.Article in journal (Refereed) Published
Abstract [en]

The prevalence of the plasmid-mediated quinolone resistance genes qnr and aac(6')-Ib-cr was investigated among clinical isolates of Escherichia coli and Klebsiella spp. selected from 2 collections of consecutive isolates collected in 2004 to 2005 in Norway (n = 2479) and Sweden (n = 2980) and 1 group of extended-spectrum beta-lactamase (ESBL)-producing isolates collected in 2003 in Norway (n = 71). A total of 414 isolates was selected for screening based on resistance to nalidixic acid and/or reduced susceptibility/resistance to ciprofloxacin. The prevalence of both qnr and aac(6')-Ib-cr was higher among the ESBL producers (9.1% and 52.3%, respectively) than in the consecutive isolates (1.1% and 3.2%, respectively). qnrS1 was detected in 6 isolates, whereas qnrB1 and qnrB7 were detected in 2 isolates. The genetic structure surrounding qnrS1 was similar to previously described structures. In 2 isolates, qnrS1 was located on conjugative IncN-type plasmids of approximately 140 kb.

Place, publisher, year, edition, pages
2010. Vol. 66, no 4, 425-431 p.
Keyword [en]
aac(6′)-Ib-cr, Consecutive isolates, Enterobacteriaceae, ESBL, LAP-2, Plasmid-mediated quinolone resistance, qnr, Replicon typing, S1 nuclease
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135728DOI: 10.1016/j.diagmicrobio.2009.12.004ISI: 000275973200012PubMedID: 20226333OAI: oai:DiVA.org:uu-135728DiVA: diva2:375440
Available from: 2010-12-08 Created: 2010-12-08 Last updated: 2010-12-20Bibliographically approved

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