uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A Longitudinal, Integrated, Clinical, Histological and mRNA Profiling Study of Resistance Exercise in Myositis
Show others and affiliations
2010 (English)In: Molecular medicine (Cambridge, Mass. Print), ISSN 1076-1551, Vol. 16, no 11-12, 455-464 p.Article in journal (Refereed) Published
Abstract [en]

Polymyositis and dermatomyositis are orphan, chronic skeletal muscle disorders characterized by weakness, infiltrations by mononuclear inflammatory cells, and fibrosis. Until recently, patients were advised to refrain from physical activity because of fears of exacerbation of muscle inflammation. However, recent studies have shown that moderate exercise training in combination with immunosuppressive drugs can improve muscle performance. Despite the positive effects of exercise training, the molecular mechanisms underlying the exercise-associated clinical improvements remain poorly understood. The present study was designed to define, at the molecular level, the effects of resistance exercise training on muscle performance and disease progression in myositis patients. We evaluated changes in muscle strength, histology and genome-wide mRNA profiles to determine the beneficial effects of exercise and determine the possible molecular changes associated with improved muscle performance. A total of 8 myositis patients underwent a 7-wk resistance exercise training program that resulted in improved muscle strength and increased maximal oxygen uptake (VO2max). Training also resulted in marked reductions in gene expression, reflecting reductions in proinflammatory and profibrotic gene networks, changes that were also accompanied by a reduction in tissue fibrosis. Consistent with the exercise-associated increase in VO2max, a subset of transcripts was associated with a shift toward oxidative metabolism. The changes in gene expression reported in the present study are in agreement with the performance improvements induced by exercise and suggest that resistance exercise training can induce a reduction in inflammation and fibrosis in skeletal muscle.

Place, publisher, year, edition, pages
2010. Vol. 16, no 11-12, 455-464 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135328DOI: 10.2119/molmed.2010.00016ISI: 000284183600001OAI: oai:DiVA.org:uu-135328DiVA: diva2:375568
Available from: 2010-12-08 Created: 2010-12-06 Last updated: 2010-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Clinical Immunology
In the same journal
Molecular medicine (Cambridge, Mass. Print)
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 148 hits
ReferencesLink to record
Permanent link

Direct link