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Gompertz law and aging as exclusion effects
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2007 (English)In: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 8, no 5, 595-603 p.Article in journal (Refereed) Published
Abstract [en]

The exponential increase with age in mortality rate, the Gompertz law, indicates that the decrease in vitality and viability linked to aging depends on phenomena with exponential or logarithmic dynamics. Gompertz slope (α) is assumed to be a measure of aging rate, provided the studied cohort is homogeneous and in a supporting environment. The law provides no clue about the cause of aging, but may be formally correlated with various physical or mathematical functions. A possible correlation between the Ogston-Laurent exclusion equation and human aging is examined. An increase with age of an inert cross-linked insoluble protein network is assumed to result in a logarithmic decrease in water volume available to colloidal macromolecules. In this model, α is assumed to be a measure of the rate of accumulation of the polypeptide network.

Place, publisher, year, edition, pages
2007. Vol. 8, no 5, 595-603 p.
Keyword [en]
Aging, Exclusion, Gompertz slope, Insoluble protein network
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135862DOI: 10.1007/s10522-007-9092-8ISI: 000249208100014PubMedID: 17468939OAI: oai:DiVA.org:uu-135862DiVA: diva2:375716
Correction in: Biogerontology, 2010, vol. 11, issue 1, p. 123Available from: 2010-12-08 Created: 2010-12-08 Last updated: 2011-01-25Bibliographically approved

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