Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants
2010 (English)In: Free radical research, ISSN 1071-5762, Vol. 44, no 5, 522-528 p.Article in journal (Refereed) Published
The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or double dose of antioxidants was provided to the subjects. Metabolic variables, plasma antioxidants and biomarkers of oxidative stress (lipid peroxidation and DNA damage) were measured. No effect of supplementation on biomarkers of oxidative stress was observed. Both intervention groups showed substantial increases of plasma antioxidants. This study demonstrated that supplementation with a combination of antioxidants did not affect lipid peroxidation and DNA damage in overweight men, despite increased concentrations of plasma antioxidants. The absence of antioxidant supplement effect might possibly be explained by the chosen study group having a normal level of oxidative stress, duration of the intervention and/or doses of antioxidants.
Place, publisher, year, edition, pages
2010. Vol. 44, no 5, 522-528 p.
Antioxidants, oxidative stress, isoprostanes, lipid peroxidation, DNA damage, overweight
Medical and Health Sciences
Research subject Nutrition
IdentifiersURN: urn:nbn:se:uu:diva-135865DOI: 10.3109/10715761003647101ISI: 000276815300005OAI: oai:DiVA.org:uu-135865DiVA: diva2:375729