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Synthesis of Guanidinium-Modified Hyaluronic Acid Hydrogel
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry.
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2010 (English)In: Macromolecular rapid communications, ISSN 1022-1336, E-ISSN 1521-3927, Vol. 31, no 13, 1175-1180 p.Article in journal (Refereed) Published
Abstract [en]

In this report, a new guanidinylating reagent is presented, which was developed without any protection/deprotection strategy and was successfully employed for linking to hyaluronan in aqueous solution. The dually functionalised HA biopolymer bearing guanidinium and hydrazide groups was synthesised to form hydrogel in Ho less than a minute when mixed with aldehyde-modified HA. This hydrogel exhibited higher storage modulus with enhanced stability in PBS when compared to the non-guanidine-containing gel. The gel shift assay showed that this biopolymer formed a stable complex with DNA as well as efficient gene transfection to cells that express HA-receptor CD44. The toxicity studies of this polymer with fibroblast cells revealed that the cells were almost 80% viable after 4 d of incubation at high HA concentration (2.5 x 10(-3) m).

Place, publisher, year, edition, pages
2010. Vol. 31, no 13, 1175-1180 p.
Keyword [en]
biomaterials, biodegradable materials, drug delivery systems, hydrogels, matrices
National Category
Inorganic Chemistry
Research subject
Chemistry with specialization in Inorganic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-135943DOI: 10.1002/marc.200900906ISI: 000280045400009OAI: oai:DiVA.org:uu-135943DiVA: diva2:375865
Available from: 2010-12-09 Created: 2010-12-09 Last updated: 2017-12-11Bibliographically approved

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Varghese, Oommen P.Kisiel, MartaOssipov, Dmitri A.Hilborn, Jöns

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