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Speech, language, and cognitive dysfunction in children with focal epileptiform activity: A follow-up study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2010 (English)In: Epilepsy & Behavior, ISSN 1525-5050, E-ISSN 1525-5069, Vol. 18, no 3, 267-275 p.Article in journal (Refereed) Published
Abstract [en]

We reviewed the medical history, EEG recordings, and developmental milestones of 19 children with speech and language dysfunction and focal epileptiform activity. Speech, language, and neuropsychological assessments and EEG recordings were performed at follow-up, and prognostic indicators were analyzed. Three patterns of language development were observed: late start and slow development, late start and deterioration/regression, and normal start and later regression/deterioration. No differences in test results among these groups were seen, indicating a spectrum of related conditions including Landau-Kleffner syndrome and epileptic language disorder. More than half of the participants had speech and language dysfunction at follow-up. IQ levels, working memory, and processing speed were also affected. Dysfunction of auditory perception in noise was found in more than half of the participants, and dysfunction of auditory attention in all. Dysfunction of communication, oral motor ability, and stuttering were noted in a few. Family history of seizures and abundant epileptiform activity indicated a worse prognosis.

Place, publisher, year, edition, pages
2010. Vol. 18, no 3, 267-275 p.
Keyword [en]
Auditory ability, Continuous spikes and waves during, slow-wave sleep, Dichotic listening, Epileptic language disorder, Autism, Focal epileptiform activity, Follow-up, Intelligence, Landau-Kleffner syndrome, Oral motor ability
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-135954DOI: 10.1016/j.yebeh.2010.04.015ISI: 000280259500020PubMedID: 20493782OAI: oai:DiVA.org:uu-135954DiVA: diva2:375892
Available from: 2010-12-09 Created: 2010-12-09 Last updated: 2010-12-09Bibliographically approved

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