Highly Flexible Synthesis of Chiral Azacycles via Iridium-Catalyzed Hydrogenation
2010 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 132, no 26, 8880-8881 p.Article in journal (Refereed) Published
A range of saturated chiral azacycles has been prepared in high yield and with high selectivity from simple starting materials. A modular approach with ring-closing metathesis as a key step was used to produce a number of five-, six-, and seven-membered cyclic alkenes. Asymmetric hydrogenation catalyzed by N,P-ligated iridium complexes gave saturated azacycles in high optical purity. This methodology was demonstrated in the synthesis of a pharmaceutical precursor.
Place, publisher, year, edition, pages
2010. Vol. 132, no 26, 8880-8881 p.
IdentifiersURN: urn:nbn:se:uu:diva-135809DOI: 10.1021/ja103901eISI: 000279561200033PubMedID: 20557052OAI: oai:DiVA.org:uu-135809DiVA: diva2:375902