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Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-kappa B Signalling
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Pharmacology. (Cancer Pharmacology and Informatics/Rolf Larsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Pharmacology. (Cancer Pharmacology and Informatics/Rolf Larsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Pharmacology. (Cancer Pharmacology and Informatics/Rolf Larsson)
2010 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 30, no 6, 1911-1919 p.Article in journal (Refereed) Published
Abstract [en]

Background:

Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity.

Materials and Methods:

The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach.

Results:

The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappa B inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappa B translocation and activity using two NF-kappa B assays, and by the down-regulation of the expression of several NE-kappa B-related genes such as IL-1 beta and IL1R1.

Conclusion:

The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappa B pathway.

Place, publisher, year, edition, pages
2010. Vol. 30, no 6, 1911-1919 p.
Keyword [en]
Alpha terpineol, Salvia libanotica, NF-kappa B, connectivity map
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-135962ISI: 000280230300006PubMedID: 20651334OAI: oai:DiVA.org:uu-135962DiVA: diva2:375909
Available from: 2010-12-09 Created: 2010-12-09 Last updated: 2017-12-11Bibliographically approved

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