Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-kappa B Signalling
2010 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 30, no 6, 1911-1919 p.Article in journal (Refereed) Published
Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity.
Materials and Methods:
The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach.
The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-kappa B inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-kappa B translocation and activity using two NF-kappa B assays, and by the down-regulation of the expression of several NE-kappa B-related genes such as IL-1 beta and IL1R1.
The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappa B pathway.
Place, publisher, year, edition, pages
2010. Vol. 30, no 6, 1911-1919 p.
Alpha terpineol, Salvia libanotica, NF-kappa B, connectivity map
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-135962ISI: 000280230300006PubMedID: 20651334OAI: oai:DiVA.org:uu-135962DiVA: diva2:375909