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Cryptotomography: Reconstructing 3D Fourier Intensities from Randomly Oriented Single-Shot Diffraction Patterns
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2010 (English)In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 104, no 22, 225501-1-225501-5 p.Article in journal (Refereed) Published
Abstract [en]

We reconstructed the 3D Fourier intensity distribution of monodisperse prolate nanoparticles using single-shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast x-ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the expansion-maximization-compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single-shot diffraction imaging of single biomolecules.

Place, publisher, year, edition, pages
2010. Vol. 104, no 22, 225501-1-225501-5 p.
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Physical Sciences
URN: urn:nbn:se:uu:diva-136073DOI: 10.1103/PhysRevLett.104.225501ISI: 000278303000009OAI: oai:DiVA.org:uu-136073DiVA: diva2:376148
Available from: 2010-12-10 Created: 2010-12-09 Last updated: 2014-10-29Bibliographically approved

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Hajdu, JanosEkeberg, TomasMaia, Filipe R. N. C.Seibert, Marvin MarvinTimneanu, Nicusor
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