Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
2010 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 42, no 7, 579-589 p.Article in journal (Refereed) Published
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
Place, publisher, year, edition, pages
2010. Vol. 42, no 7, 579-589 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-136017DOI: 10.1038/ng.609ISI: 000279242400010OAI: oai:DiVA.org:uu-136017DiVA: diva2:376184