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Age-related changes of muscle and plasma amino acids in healthy children
Department of Surgery, Gastrocentrum, Karolinska University Hospital, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnkirurgi/Christoffersson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnkirurgi/Christoffersson)
Department of Anaesthesiology and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
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2010 (English)In: Amino Acids, ISSN 0939-4451, E-ISSN 1438-2199, Vol. 39, no 2, 359-366 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to explore if changes in muscle and plasma amino acid concentrations developed during growth and differed from levels seen in adults. The gradient and concentrations of free amino acids in muscle and plasma were investigated in relation to age in metabolic healthy children. Plasma and specimens from the abdominal muscle were obtained during elective surgery. The children were grouped into three groups (group 1: < 1 year, n = 8; group 2: 1-4 years, n = 13 and group 3: 5-15 years, n = 15). A reference group of healthy adults (21-38 years, n = 22) was included in their comparisons and reflected specific differences between children and adults. In muscle the concentrations of 8 out of 19 amino acids analysed increased with age, namely taurine, aspartate, threonine, alanine, valine, isoleucine, leucine, histidine, as well as the total sums of branched chain amino acids (BCAA), basic amino acids (BAA) and total sum of amino acids (P < 0.05). In plasma the concentrations of threonine, glutamine, valine, cysteine, methionine, leucine, lysine, tryptophane, arginine, BCAA, BAA and the essential amino acids correlated with age (P < 0.05). These results indicate that there is an age dependency of the amino acid pattern in skeletal muscle and plasma during growth.

Place, publisher, year, edition, pages
2010. Vol. 39, no 2, 359-366 p.
Keyword [en]
Amino acids, Growth, Skeletal muscle, Plasma
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-136176DOI: 10.1007/s00726-009-0446-1ISI: 000279190400004OAI: oai:DiVA.org:uu-136176DiVA: diva2:376299
Available from: 2010-12-10 Created: 2010-12-10 Last updated: 2011-08-10Bibliographically approved

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Angsten, GertrudMeurling, Staffan

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