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Effect of Muscarinic and Nicotinic Receptor Antagonism on Rat Gastric Motor Activity
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2010 (English)In: Pharmacology, ISSN 0031-7012, E-ISSN 1423-0313, Vol. 85, no 5, 272-279 p.Article in journal (Refereed) Published
Abstract [en]

Background/Aims: Our aim was to investigate whether muscarinic and nicotinic receptors mediate nitric oxide release during motor events in the rat stomach. Methods: Isolated rat stomach volume changes were monitored in an organ bath setup with an intragastric balloon coupled to a barostat and studied in basal conditions and during electrical vagal stimulation (EVS). In conscious rats, the intragastric pressure (IGP) was measured during test meal infusion. Results: In the presence of N-G-nitro-L -arginine methyl ester (L-NAME; 0.1 mmol/l), EVS induced significant gastric contractions (mean +/- SEM = 0.27 +/- 0.04 ml; n = 6) that could be blocked by atropine (3 mu mol/l) and hexamethonium (0.1 mmol/l). In the presence of atropine and/or hexamethonium, EVS-induced relaxations could not be blocked by L-NAME, while exogenous nitric oxide could still relax the stomach. In conscious rats, atropine (1 mg kg(-1)) initially decreased IGP, while during further distension it increased IGP. In the presence of L -NAME (30 mg kg(-1)) atropine consistently decreased IGP.

Place, publisher, year, edition, pages
2010. Vol. 85, no 5, 272-279 p.
Keyword [en]
Cholinergic nerves
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-136202DOI: 10.1159/000285116ISI: 000278132000003PubMedID: 20375537OAI: oai:DiVA.org:uu-136202DiVA: diva2:376451
Available from: 2010-12-10 Created: 2010-12-10 Last updated: 2010-12-10Bibliographically approved

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