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The Swedish reflux trial in children: IV. Renal damage
Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.ORCID iD: 0000-0002-4590-4957
Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden.
Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Göteborg, Sweden.
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2010 (English)In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 184, no 1, 292-297 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: We compared the development of new renal damage in small children with dilating vesicoureteral reflux randomly allocated to antibiotic prophylaxis, endoscopic treatment or surveillance as the control group. MATERIALS AND METHODS: Included in the study were 128 girls and 75 boys 1 to younger than 2 years with grade III-IV reflux. Voiding cystourethrography and dimercapto-succinic acid scintigraphy were done before randomization and after 2 years. Febrile urinary tract infections were recorded during followup. Data analysis was done by the intent to treat principle. RESULTS: New renal damage in a previously unscarred area was seen in 13 girls and 2 boys. Eight of the 13 girls were on surveillance, 5 received endoscopic therapy and none were on prophylaxis (p = 0.0155). New damage was more common in children with than without febrile recurrence (11 of 49 or 22% vs 4 of 152 or 3%, p <0.0001). CONCLUSIONS: In boys the rate of new renal damage was low. It was significantly higher in girls and most common in the control surveillance group. There was also a strong association between recurrent febrile UTIs and new renal damage in girls.

Place, publisher, year, edition, pages
2010. Vol. 184, no 1, 292-297 p.
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Pediatrics
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URN: urn:nbn:se:uu:diva-136223DOI: 10.1016/j.juro.2010.01.060ISI: 000278642300102PubMedID: 20494369OAI: oai:DiVA.org:uu-136223DiVA: diva2:376488
Available from: 2010-12-10 Created: 2010-12-10 Last updated: 2017-12-11

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