Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
2010 (English)In: Developmental Dynamics, ISSN 1058-8388, E-ISSN 1097-0177, Vol. 239, no 6, 1858-1866 p.Article in journal (Refereed) Published
Muller cells in the chick retina are generally thought to be a homogeneous population. We show that the transcription factor Pax2 is expressed by Muller cells in the central chick retina and its expression was first observed at stage 32 (embryonic day [E] 7.5). Birth-dating indicated that the majority of Pax2-positive Muller cells are generated between stage 29 and 33 (E5.5-E8). At stage 42 (E16), several Muller cell markers, such as Sox2 and 2M6, had reached the peripheral retina, while the Pax2 labeling extended approximately half-way. A similar pattern was maintained in the 6-month-old chicken. Neither the Pax2-positive nor the Pax2-negative Muller cells could be specifically associated to proliferative responses in the retina induced by growth factors or N-methyl-D-aspartate. Pax2 was not detected in Muller cells in mouse, rat, guinea-pig, rabbit, or pig retinas; but the zebrafish retina displayed a similar pattern of central Pax2-expressing Muller cells.
Place, publisher, year, edition, pages
2010. Vol. 239, no 6, 1858-1866 p.
avascular, development, EdU, glia, Muller glia, regeneration, Sox2, zebrafish
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-136282DOI: 10.1002/dvdy.22309ISI: 000278761700027OAI: oai:DiVA.org:uu-136282DiVA: diva2:376542