Automated synthesis of F-18-labelled analogs of metomidate, vorozole and harmine using commercial platform
2010 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 53, no 3-4, 169-171 p.Article in journal (Refereed) Published
Three F-18-labelled PET tracers, 2-[F-18]fluoroethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate ([F-18]FETO), 6-[(S)-(4-chlorophenyl)-(1H)-1,2,4-triazol-1-yl)methyl]-1-(2-[F-18]fluor oethyl)-1H-benzotriazole ([F-18]FVOZ) and 7-[2-(2-[F-18]fluoroethoxy)ethoxy]-1-9H-beta-carboline ([F-18]FHAR) were synthesized by a one-step nucleophilic fluorination using the automated commercial platform TRACERLab FXFN. The labelled products were obtained with 16-20% isolated decay corrected radiochemical yields after 70-75 min synthesis time. The radiochemical and chemical purities were more than 98% in all cases. The synthesis using commercial platform may make these tracers more accessible for clinical research.
Place, publisher, year, edition, pages
2010. Vol. 53, no 3-4, 169-171 p.
PET, F-18-labelling, [F-18]FETO, [F-18]FVOZ, [F-18]FHAR, automated synthesis
IdentifiersURN: urn:nbn:se:uu:diva-136437DOI: 10.1002/jlcr.1742ISI: 000277757000032OAI: oai:DiVA.org:uu-136437DiVA: diva2:376941