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Automated synthesis of F-18-labelled analogs of metomidate, vorozole and harmine using commercial platform
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
2010 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 53, no 3-4, 169-171 p.Article in journal (Refereed) Published
Abstract [en]

Three F-18-labelled PET tracers, 2-[F-18]fluoroethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate ([F-18]FETO), 6-[(S)-(4-chlorophenyl)-(1H)-1,2,4-triazol-1-yl)methyl]-1-(2-[F-18]fluor oethyl)-1H-benzotriazole ([F-18]FVOZ) and 7-[2-(2-[F-18]fluoroethoxy)ethoxy]-1-9H-beta-carboline ([F-18]FHAR) were synthesized by a one-step nucleophilic fluorination using the automated commercial platform TRACERLab FXFN. The labelled products were obtained with 16-20% isolated decay corrected radiochemical yields after 70-75 min synthesis time. The radiochemical and chemical purities were more than 98% in all cases. The synthesis using commercial platform may make these tracers more accessible for clinical research.

Place, publisher, year, edition, pages
2010. Vol. 53, no 3-4, 169-171 p.
Keyword [en]
PET, F-18-labelling, [F-18]FETO, [F-18]FVOZ, [F-18]FHAR, automated synthesis
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-136437DOI: 10.1002/jlcr.1742ISI: 000277757000032OAI: oai:DiVA.org:uu-136437DiVA: diva2:376941
Available from: 2010-12-13 Created: 2010-12-13 Last updated: 2017-12-11Bibliographically approved

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