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High frequency of lactose intolerance in a prehistoric hunter-gatherer population in northern Europe
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
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2010 (English)In: BMC Evolutionary Biology, ISSN 1471-2148, E-ISSN 1471-2148, Vol. 10, 89- p.Article in journal (Refereed) Published
Abstract [en]

Background: Genes and culture are believed to interact, but it has been difficult to find direct evidence for the process. One candidate example that has been put forward is lactase persistence in adulthood, i.e. the ability to continue digesting the milk sugar lactose after childhood, facilitating the consumption of raw milk. This genetic trait is believed to have evolved within a short time period and to be related with the emergence of sedentary agriculture. Results: Here we investigate the frequency of an allele (-13910*T) associated with lactase persistence in a Neolithic Scandinavian population. From the 14 individuals originally examined, 10 yielded reliable results. We find that the T allele frequency was very low (5%) in this Middle Neolithic hunter-gatherer population, and that the frequency is dramatically different from the extant Swedish population (74%). Conclusions: We conclude that this difference in frequency could not have arisen by genetic drift and is either due to selection or, more likely, replacement of hunter-gatherer populations by sedentary agriculturalists.

Place, publisher, year, edition, pages
2010. Vol. 10, 89- p.
National Category
Biological Sciences Archaeology
URN: urn:nbn:se:uu:diva-136319DOI: 10.1186/1471-2148-10-89ISI: 000277269900001OAI: oai:DiVA.org:uu-136319DiVA: diva2:377021
Available from: 2010-12-13 Created: 2010-12-11 Last updated: 2016-04-26Bibliographically approved

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Malmström, HelenaJakobsson, Mattias
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