Sex-specific heritability of cell-mediated immune response in the blue tit nestlings (Cyanistes caeruleus)
2010 (English)In: Journal of Evolutionary Biology, ISSN 1010-061X, E-ISSN 1420-9101, Vol. 23, no 6, 1286-1292 p.Article in journal (Refereed) Published
Here, we aimed at estimating sex-specific heritabilities of cell-mediated immune response (CMI) in the blue tit nestlings (Cyanistes caeruleus). To separate genetic and environmental components of the phenotypic variance in CMI (measured using phytohaemagglutinin assay), we performed a cross-fostering experiment. Additionally, controlled environmental variation was introduced by enlarging some broods. Our analyses revealed a significant genetic component (as approximated by the nest-of-origin term) of the phenotypic variance in immune response. More importantly, these genetic effects differed between sexes and experimentally manipulated brood sizes, as indicated by significant genotype-by-sex and genotype-by-environment interactions. We discuss possible causes of such sexual dimorphism in gene expression and suggest that sex- and environment-specific genetic interactions may contribute to the maintenance of genetic variability in traits related to immune functions.
Place, publisher, year, edition, pages
2010. Vol. 23, no 6, 1286-1292 p.
blue tit, cell-mediated immunity, evolutionary immunology, GEI, genetic correlation, genotype-by-environment interaction, genotype-by-sex interaction, heritability, phytohaemagglutinin
IdentifiersURN: urn:nbn:se:uu:diva-136566DOI: 10.1111/j.1420-9101.2010.01993.xISI: 000277710100016PubMedID: 20456564OAI: oai:DiVA.org:uu-136566DiVA: diva2:377308