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Anti-preS responses influence the anti-HBs response in newborns after vaccination with the third generation Sci-B-Vac (TM) vaccine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
2009 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 28, no 2, 446-451 p.Article in journal (Refereed) Published
Abstract [en]

We analysed the specificity and significance of the antibody response towards the linear preS1 sequence that has been shown to represent the "hepatocyte binding site" comprising amino acids preS1 (21-47) or the specific preS2 (131-140) antibody response to the "polymerised albumin receptor" in relation to the antibody response to hepatitis B surface antigen during immunisation of healthy children with the preS-containing Sci-B-Vac (TM) vaccine. Twenty-eight healthy newborns received three doses of the Sci-B-Vac (TM) vaccine according to a 0, 1-, and 6-month scheme. Seventeen (61%) of the 28 newborns had detectable levels of anti-preS1 (21-47) antibodies and 14 (50%) were anti-preS2 (131-140) reactive at 6 and/or 9 months after initiation of the vaccination. The mean levels of anti-HBs were significantly higher in the anti-preS2 (131-140) non-reactive (24 580 +/- 7815 IU/l, mean + SEM) compared with the reactive sera (7287 +/- 2317 IU/l, p < 0.025). The highest anti-HBs levels were found in newborns who exhibited reactivity towards the aa 21-47 of the preS1 but lacked anti-preS2 (131-140) reactivity. (C) 2009 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2009. Vol. 28, no 2, 446-451 p.
Keyword [en]
preS antibodies, Polymerised albumin receptor, Hepatocyte binding site
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-136720DOI: 10.1016/j.vaccine.2009.10.023ISI: 000274869300022OAI: oai:DiVA.org:uu-136720DiVA: diva2:377481
Available from: 2010-12-14 Created: 2010-12-14 Last updated: 2010-12-14Bibliographically approved

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