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Biological AMS at Uppsala University: Status report
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Ion Physics.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Ion Physics.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Ion Physics.
2010 (English)In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, ISSN 0168-583X, E-ISSN 1872-9584, Vol. 268, no 7-8, 884-886 p.Article in journal (Refereed) Published
Abstract [en]

In January 2007 a new research program was initiated at Uppsala University focusing on the biological applications of AMS. We have used a 5 MV Pelletron Tandem accelerator to study biological samples. With Microdosing applications in mind, a variety of measurements have been performed on human blood, plasma and urine that have been labeled with a C-14-labeled pharmaceutical drug covering a concentration range, spanning 3 orders of magnitude. Furthermore, by studying small sample amounts and low concentrations, we have demonstrated sensitivity in the hundred zeptomole range for a small pharmaceutical substance in human blood. Another application of interest, based on the enhanced C-14 activity from the cold war bomb-peak, is dating of DNA molecules providing fundamental data for the regenerative medicine and stem cell research community. We show data on a sensitive carrier method for measuring the isotopic ratio of small biological sample in the few mu gC range.

Place, publisher, year, edition, pages
2010. Vol. 268, no 7-8, 884-886 p.
Keyword [en]
AMS, Biological Accelerator Mass Spectrometry, DNA, Microdosing
National Category
Subatomic Physics
Identifiers
URN: urn:nbn:se:uu:diva-136899DOI: 10.1016/j.nimb.2009.10.055ISI: 000277462300051OAI: oai:DiVA.org:uu-136899DiVA: diva2:377652
Available from: 2010-12-14 Created: 2010-12-14 Last updated: 2017-12-11Bibliographically approved

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Salehpour, Mehran

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