Biological AMS at Uppsala University: Status report
2010 (English)In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, ISSN 0168-583X, Vol. 268, no 7-8, 884-886 p.Article in journal (Refereed) Published
In January 2007 a new research program was initiated at Uppsala University focusing on the biological applications of AMS. We have used a 5 MV Pelletron Tandem accelerator to study biological samples. With Microdosing applications in mind, a variety of measurements have been performed on human blood, plasma and urine that have been labeled with a C-14-labeled pharmaceutical drug covering a concentration range, spanning 3 orders of magnitude. Furthermore, by studying small sample amounts and low concentrations, we have demonstrated sensitivity in the hundred zeptomole range for a small pharmaceutical substance in human blood. Another application of interest, based on the enhanced C-14 activity from the cold war bomb-peak, is dating of DNA molecules providing fundamental data for the regenerative medicine and stem cell research community. We show data on a sensitive carrier method for measuring the isotopic ratio of small biological sample in the few mu gC range.
Place, publisher, year, edition, pages
2010. Vol. 268, no 7-8, 884-886 p.
AMS, Biological Accelerator Mass Spectrometry, DNA, Microdosing
IdentifiersURN: urn:nbn:se:uu:diva-136899DOI: 10.1016/j.nimb.2009.10.055ISI: 000277462300051OAI: oai:DiVA.org:uu-136899DiVA: diva2:377652